30% of common colds stem from four seasonal coronaviruses. A study showed over 90% of Vancouver's population had prior exposure to these coronaviruses by June 2020, despite low clinical COVID-19 cases. Natural immunity likely influenced COVID-19 outcomes, affecting younger individuals less severely than older adults with comorbidities. The Great Barrington Declaration emphasized protecting frail seniors and allowing others to live normally without lockdowns.
Majority had Pre-Pandemic Common Coronavirus Infection Four Seasonal Colds HKU1, OC43, NL63, 229E, May Explain Why Some Faired Better than Others Fri, 11 Oct 2024 09:41:03 GMT https://petermcculloughmd.substack.com/p/majority-had-pre-pandemic-common By Peter A. McCullough, MD, MPH
Approximately 30% of common colds are caused by four seasonal human coronaviruses identified by Spike proteins HKU1, OC43, NL63, and 229E.
A detailed serologic analysis by Majdoubi et al from British Columbia found that June 19, 2020, when <1% of the Vancouver population had clinical COVID-19, >90% had evidence of prior infection with one of the four human or natural coronaviruses.
Majdoubi A, Michalski C, O'Connell SE, Dada S, Narpala S, Gelinas J, Mehta D, Cheung C, Winkler DF, Basappa M, Liu AC, Görges M, Barakauskas VE, Irvine M, Mehalko J, Esposito D, Sekirov I, Jassem AN, Goldfarb DM, Pelech S, Douek DC, McDermott AB, Lavoie PM. A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2. JCI Insight. 2021 Apr 22;6(8):e146316. doi: 10.1172/jci.insight.146316. PMID: 33720905; PMCID: PMC8119195.
Because of the common structures between the strains, the question arises: did levels of prior immunity provider greater or lesser degrees of protection for soon-to-be COVID-19 victims? It was interesting that we did not hear about high mortality rates among children, daycare workers, teachers, and healthcare workers who would have had frequent and routine exposures to one or more of the common cold coronaviruses. Instead it was older more secluded adults with comorbidities who were at highest risk.
If we have learned anything, natural immunity and its proxies including frequent contact with respiratory viruses played a large role in how we should have managed the pandemic. The Great Barrington Declaration , originally published on October 4, 2020, and celebrating its fourth anniversary was right from so many perspectives. Only frail seniors needed special protections, others should have gone about normal life without lockdowns or restrictions and we should have treated high risk cases in the community with the McCullough Protocol .
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Peter A. McCullough, MD, MPH
President, McCullough Foundation
Majdoubi A, Michalski C, O'Connell SE, Dada S, Narpala S, Gelinas J, Mehta D, Cheung C, Winkler DF, Basappa M, Liu AC, Görges M, Barakauskas VE, Irvine M, Mehalko J, Esposito D, Sekirov I, Jassem AN, Goldfarb DM, Pelech S, Douek DC, McDermott AB, Lavoie PM. A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2. JCI Insight. 2021 Apr 22;6(8):e146316. doi: 10.1172/jci.insight.146316. PMID: 33720905; PMCID: PMC8119195.