Majority of Monkeypox cases in the US are in HIV-positive gay/bisexual men. A meta-analysis of 37 studies (57,693 participants) showed Smallpox vaccination offers partial protection against Monkeypox: lower infection and severe case rates in vaccinated individuals. Particularly, third-generation vaccines were more effective. Those over 51 with HIV or gay/bisexual lifestyles may have 64% theoretical protection. Safe sex practices and antivirals are recommended.
Antecedent Smallpox Vaccination Partially Protects Against Monkeypox Salutary Legacy Effect Demonstrated in Meta-Analysis of 37 Studies Fri, 23 Aug 2024 09:33:00 GMT https://petermcculloughmd.substack.com/p/antecedent-smallpox-vaccination-partially By Peter A. McCullough, MD, MPH
The majority of serious Monkeypox cases in the United States have occurred in HIV positive gay or bisexual men. Because Monkeypox is related to Smallpox, the question has arisen, do previously vaccinated persons for Smallpox have any lasting protection against Monkeypox? Smallpox vaccination ended in the US in 1972.
Liu et al performed a meta-analysis to evaluate the theoretical impact of Smallpox vaccination on the current Monkeypox outbreak.
“A total of 37 studies with 57,693 participants were included in the final analysis. The effectiveness data showed that monkeypox infection rates were lower in the smallpox-vaccinated group than in the unvaccinated group (risk ratio [RR]: 0.46; 95% confidence interval [CI]: 0.31–0.68). The protection data showed that smallpox vaccination effectively reduced the risk of severe monkeypox infection (RR: 0.61; 95% CI: 0.42–0.87). Third-generation vaccines showed greater efficacy (RR: 0.36, 95% CI: 0.22–0.56) than first-generation vaccines.”
So for those over age 51 in the United States with HIV or gay/bisexual lifestyles there is partial (64%) theoretical protection from Smallpox vaccines against Monkeypox. Safe sex practices are advised and when a rash arises, the oral/intravenous antiviral tecovirimat is highly effective in resolving the illness.
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Peter A. McCullough, MD, MPH
President, McCullough Foundation
Liu H, Wang W, Zhang Y, Wang F, Duan J, Huang T, Huang X, Zhang T. Global Perspectives on Smallpox Vaccine against Monkeypox: A Comprehensive Meta-Analysis and Systematic Review of Effectiveness, Protection, Safety and Cross-immunogenicity. Emerg Microbes Infect. 2024 Jul 31:2387442. doi: 10.1080/22221751.2024.2387442. Epub ahead of print. PMID: 39082272.